AI-Driven Early Warning of Cardiovascular Abnormalities Using Continuous Wearable Biosensing
Keywords:
cardiovascular early warning, wearable biosensing, artificial intelligence, digital health governance, federated learning, robustness, health equityAbstract
Continuous wearable biosensing is shifting cardiovascular care from episodic hospital measurement toward longitudinal, ambient data collection, creating new possibilities for early detection of arrhythmias, ischemic patterns, and hemodynamic instability. However, the translation of this sensing capability into reliable early warning systems requires more than improved classification accuracy. It demands careful integration of sensing hardware, embedded computation, network infrastructure, learning pipelines, clinical workflows, and regulatory oversight. This paper presents a system-level analysis of artificial intelligence driven early warning architectures for cardiovascular abnormalities using wearable biosensors. It examines trade-offs between on-device and cloud inference, constraints on energy and data quality, the influence of motion artifacts and heterogeneous sensor modalities, and the organizational arrangements required for safe deployment. The discussion addresses robustness under dynamic ambulatory conditions, fairness across diverse populations, privacy-preserving learning approaches such as federated systems, and the governance mechanisms needed to maintain clinical trust. Rather than focusing on a single algorithm or sensor, the paper argues that sustainable early warning depends on a layered socio-technical infrastructure in which algorithmic performance is coupled with data stewardship, infrastructure resilience, and accountability. The analysis draws on current evidence from wearable photoplethysmography and electrocardiography studies, machine learning deployment research, and health data governance scholarship to articulate structural design principles for future cardiovascular biosensing systems.
References
1. Majumder, S., Mondal, T., & Deen, M. J. (2017). Wearable sensors for remote health monitoring. Sensors, 17(1), 130.
2. Allen, J. (2007). Photoplethysmography and its application in clinical physiological measurement. Physiological Measurement, 28(3), R1–R39.
3. Tison, G. H., Sanchez, J. M., Ballinger, B., Singh, A., Olgin, J. E., Pletcher, M. J., Vittinghoff, E., Lee, E. S., Fan, S. M., Gladstone, R. A., Mikell, C., Sohoni, N., Hsieh, J., & Marcus, G. M. (2018). Passive detection of atrial fibrillation using a commercially available smartwatch. JAMA Cardiology, 3(5), 409–416.
4. Perez, M. V., Mahaffey, K. W., Hedlin, H., Rumsfeld, J. S., Garcia, A., Ferris, T., Balasubramanian, V., Russo, A. M., Rajmane, A., Cheung, L., Hung, G., Lee, J., Kowey, P., Talati, N., Nag, D., Gummidipundi, S. E., Beatty, A., Hills, M. T., Desai, S., ... Turakhia, M. P. (2019). Large-scale assessment of a smartwatch to identify atrial fibrillation. New England Journal of Medicine, 381(20), 1909–1917.
5. Hannun, A. Y., Rajpurkar, P., Haghpanahi, M., Tison, G. H., Bourn, C., Turakhia, M. P., & Ng, A. Y. (2019). Cardiologist-level arrhythmia detection with ambulatory ECG. Nature Medicine, 25(1), 65–69.
6. Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K., Cui, C., Corrado, G., Thrun, S., & Dean, J. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24–29.
7. Topol, E. J. (2019). High-performance medicine: The convergence of human and artificial intelligence. Nature Medicine, 25(1), 44–56.
8. Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., Gilbert, A., Fernandes, J. F., Bukhari, H. A., Wajdan, A., Martinez, M. V., Santos, M. S., Shamohammdi, M., Luo, H., Westphal, P., Leeson, P., DiAchille, P., Gurev, V., Mayr, M., ... Lamata, P. (2020). The digital twin to enable the vision of precision cardiology. European Heart Journal, 41(48), 4556–4564.
9. Rieke, N., Hancox, J., Li, W., Milletari, F., Roth, H. R., Albarqouni, S., Bakas, S., Galtier, M. N., Landman, B. A., Maier-Hein, K., Ourselin, S., Sheller, M., Summers, R. M., Trask, A., Xu, D., Baust, M., & Cardoso, M. J. (2020). The future of digital health with federated learning. NPJ Digital Medicine, 3, 119.
10. Price, W. N., & Cohen, I. G. (2019). Privacy in the age of medical big data. Nature Medicine, 25(1), 37–43.
11. Obermeyer, Z., Powers, B., Vogeli, C., & Mullainathan, S. (2019). Dissecting racial bias in an algorithm used to manage the health of populations. Science, 366(6464), 447–453.
12. Rajkomar, A., Hardt, M., Howell, M. D., Corrado, G., & Chin, M. H. (2018). Ensuring fairness in machine learning to advance health equity. Annals of Internal Medicine, 169(12), 866–872.
13. Subbaswamy, A., & Saria, S. (2020). From development to deployment: Dataset shift, causality, and shift-stable models in health AI. Biostatistics, 21(2), 345–352.
14. Zheng, X., Hu, S., Dwyer, V., Barrett, L., & Derakhshani, M. (2026). Joint attention mechanism learning to facilitate opto-physiological monitoring during physical activity. Biomedical Signal Processing and Control, 113, 108949.
15. Murshed, M. G. S., Murphy, C., Hou, D., Khan, N., Ananthanarayanan, G., & Hussain, F. (2021). Machine learning at the network edge: A survey. ACM Computing Surveys, 54(8), 1–37.
16. Rault, T., Bouabdallah, A., Challal, Y., & Marin, F. (2017). A survey of energy-efficient context recognition systems using wearable sensors for healthcare. Personal and Ubiquitous Computing, 21(4), 607–619.
17. Sculley, D., Holt, G., Golovin, D., Davydov, E., Phillips, T., Ebner, D., Chaudhary, V., Young, M., Crespo, J. F., & Dennison, D. (2015). Hidden technical debt in machine learning systems. In Advances in neural information processing systems 28 (pp. 2503–2511).
18. Benjamens, S., Dhunnoo, P., & Meskó, B. (2020). The state of artificial intelligence-based FDA-approved medical devices and algorithms: An online database. NPJ Digital Medicine, 3, 118.
19. Lyles, C. R., Wachter, R. M., & Sarkar, U. (2021). Focusing on digital health equity. JAMA, 326(18), 1795–1796.
20. Vayena, E., Blasimme, A., & Cohen, I. G. (2018). Machine learning in medicine: Addressing ethical challenges. PLoS Medicine, 15(11), e1002689.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Artificial Intelligence and Machine Learning Systems

This work is licensed under a Creative Commons Attribution 4.0 International License.